The 4Kscore Test is appropriate for the following men:

• Men 45-54 years old and total PSA ≥2 ng/mL and/or abnormal DRE
• Men 55-75 years old and total PSA ≥3 ng/mL and/or abnormal DRE
• Men ≥76 years old and total PSA ≥4 ng/mL and/or abnormal DRE

The 4Kscore measures 4 kallikreins (proteins) in the blood: Total PSA, FreePSA, Intact PSA and hK2. These results are combined with clinical information into an algorithm to determine a score that reflects the risk of having prostate cancer. See a 4Kscore sample result report and learn more about interpreting them.

It’s important for you to talk to your healthcare provider about any test results. In general, the 4Kscore results include a range for probability of prostate cancer risk:

• Low risk: 1%-7.5%
• Intermediate risk: 7.5%-20%
• High risk: 20%->90%

The 4KScore also calculates a probability of not developing distant metastases within the next 10 years. See a sample of a 4Kscore result report and learn more about how to interpret these results.

Although there are many factors that contribute to your healthcare provider’s decision to conduct a prostate biopsy, there are several urinary and blood based PCMs that may help guide you and your physician through the decision of conducting a prostate biopsy. These include:

• Select mdx
• 4K
• Prostate health index (phi)
• ExoDx
• MPS2

Genetic tests also may be worth considering if you have a family history of prostate cancer, breast cancer, ovarian cancer or colorectal cancer. These genetic tests are recommended for men who are determined through genetic counseling to be at potential risk for hereditary cancer:

• Myriad myRisk
• ProstateNext
• Ambry Score

The benefits of the 4Kscore® Test are the following:

• It provides you and your physician with the probability of finding high-grade, aggressive prostate cancer (Gleason score ≥7) if you undergo a prostate biopsy
• It can so the long-term probability of cancer metastasis or death from prostate cancer

Both of these test benefits provide you and your physician with more information so that you can make better-informed healthcare decisions.

The 4Kscore® Test is covered by most leading healthcare insurance plans. Your provider will bill your insurance company, and you will only be responsible for applicable copayment, co-insurance, and/or deductible amounts. For non-covered services, BioReference Laboratories, Inc. and their GenPath division also have self-pay and payment plan options available.